I'm never good when it comes to clothes and stuff like that. I do buy a shirt or two for the wife, but most of it is stuff she may not be buying for herself.
For my parents and brothers, it is a bit different. Typically gift cards, or something unique if I can find something they may not have. Anymore though everyone just asks for gc's.
I've had bad luck with the wifes side, and she and I have both agreed, gc's for them, not even going to try anymore.